Assistant Professor, Department of Medicine at Washington University in St. Louis
Lisa de las Fuentes, MD
Assistant Professor, Department of Medicine at Washington University in St. Louis
Office: Department of Medicine, Cardiovascular Division
660 South Euclid Avenue
Campus Box 8086
Saint Louis, MO 63110
Phone: 314-747-8163
Fax: 314-747-8170
Email: lfuentes@wustl.edu
Mentors
Victor Dávila-Román, MD
Professor of Medicine, Anesthesiology & Radiology
Washington University School of Medicine
D. C. Rao, PhD
Professor of Biostatistics
Washington University School of Medicine
Education
BA, Stanford University, Stanford, CA – 1987-1991
MD, University of Texas Southwestern Medical School, Dallas, TX – 1992-1996
MA, Washington University, Department of Biostatistics, St. Louis, MO – 2003-present
Training
Internship/Residency, Internal Medicine, Parkland Memorial Hospital/Dallas Veteran’s Administration Hospital, University of Texas Southwestern Medical School, Dallas, TX – 1996-1999
Adult Cardiovascular Fellowship Training – Clinical, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, MO – 1999-2001
Adult Cardiovascular Fellowship Training – Research, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, MO – 2001-2003
Nuclear Cardiology Fellowship, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO – 1999-2003
Instructor of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis , MO – 2003-2005
Co-Vice Chair, Institutional Review Board Committee, Washington University School of Medicine, St. Louis, MO – 2004-present
Co-Director, Cardiovascular Imaging and Clinical Research Core Laboratory, Washington University School of Medicine, St. Louis, MO – 2005-present
Early Career Liaison, Functional Genomics and Translational Biology Interdisciplinary Working Group, American Heart Association – 2006-present
Assistant Professor of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO – 2006-present
Area of Specialization / Research Interests
Genetics determinants of hypertension, left ventricular hypertrophy, dilated cardiomyopathy, and other cardiovascular and metabolic diseases.
Profile
Lisa de las Fuentes, MD received her BA in Human Biology from Stanford University and her MD from the University of Texas Southwestern Medical School where she was induced into Alpha Omega Alpha and awarded the Richard Mays Smith Award for accomplishment in Internal Medicine. She remained at the University of Texas Southwestern for her internship and residency in Internal Medicine (1996). During her four-year fellowship in Cardiovascular Diseases at Washington University School of Medicine, she obtained training on clinical and research applications of non-invasive imaging including echocardiography, nuclear cardiology, cardiac magnetic resonance imaging, and vascular sonography. She was awarded the Burton E. Sobel Award for Excellence in Cardiovascular Research (2003). Dr. de las Fuentes is enrolled in the Genetic Epidemiology Master in Science program at Washington University; she was awarded a “Certificate” in 2005 and is currently working towards her Masters Degree in the program.
Dr. de las Fuentes’ ongoing clinical and translational research projects investigate the role played by common genetic variants in myocardial metabolism genes in modulating the hypertensive cardiovascular disease phenotype in humans. Of particular interest are the genetic, metabolic, and environmental predictors of left ventricular hypertrophy, left ventricular dysfunction, and vascular hypertrophy. In addition to presentations at multiple national scientific meetings, Dr. de las Fuentes’ research has been published in a variety of journals including the Journal of the American College of Cardiology, Hypertension, Journal of the American Society of Echocardiograph, Journal of Nuclear Cardiology, Current Hypertension Reports, and Journal of Heart and Lung Transplantation.
Dr. de las Fuentes received a career award from the Robert Wood Johnson Foundation’s Amos Medical Faculty Development Program (2003-07) supporting her research in cardiovascular genetics. She received additional awards from the Sandra A. Daugherty Foundation Cardiovascular Epidemiology and Prevention Grant (2004) and from the SeattleSNPs Program in Genomic Applications (2005). As a Multidisciplinary Clinical Research Scholar, Dr. de las Fuentes continues her studies investigating how single nucleotide polymorphisms in key myocardial metabolism genes modulate the hypertrophic phenotype. Additional studies focus on how the systemic metabolic environment interacts with genetic variants to increase cardiovascular risk in patients with diabetes, obesity, and the metabolic syndrome.
Among her clinical activities, Dr. de las Fuentes an Assistant Professor in Medicine and attending Cardiologist at Barnes-Jewish Hospital and the Heart Care Institute, Saint Louis, MO. She is also Vice Chairperson of an Institution Review Board Continuing Review Committee and was recently named as an Early Career Liaison for the American Heart Association’s Interdisciplinary Working Group on Functional Genomics and Translational Biology.
Recent Grant Support
Granting agency: Robert Wood Johnson Foundation
Role: Principal Investigator
Duration: July 1, 2003 - June 30, 2007
Title: Genetics Determinants of Left Ventricular Hypertrophy: Correlates with Myocardial Fatty Acid Metabolism
Purpose: The influence of common genetic variations in the PPARα complex genes on the left ventricular hypertrophic phenotype are assessed in this genotype-phenotype association study.
Granting agency: Sandra A. Daugherty Foundation
Role: Principal Investigator
Duration: September 1, 2004 - August 31, 2006
Title: A Candidate-Gene Association Study to Evaluate Non-Traditional Risk Factors in the Epidemiology of Hypertension
Purpose: The influence of common genetic variations in the RGS2 and RGS4 genes on the hypertensive and left ventricular hypertrophic phenotypes are assessed in this genotype-phenotype association study.
Granting agency: SeattleSNPs Program for Genomic Applications
Role: Principal Investigator
Duration: September, 2006
Title: Genetic Determinants of LV Hypertrophy: Correlates with PPARα Regulatory Complex Variants
Purpose: Approximately 100 single nucleotide polymorphisms in >500 individuals with hypertensive heart disease will be genotyped at no cost for use in a haplotype-phenotype association study.
Granting agency: National Institutes of Health (PI: Victoria Fraser)
Role: Scholar
Duration: July 2006 - October 2009
Title: K12 Multidisciplinary Clinical Research Career Development Program
Purpose: This institutional grant program offers didactic training and hands-on clinical research training and mentorship with an emphasis on multidisciplinary clinical research.
Granting agency: National Institutes of Health (PI: Clay Semenkovich)
Role: Co-Investigator
Title: SCCOR in Vascular Injury, Repair, and Remodeling
Duration: April 2006 - March 2010
Project Core: Vascular Imaging Core
Purpose: Investigation of the interaction between genetic variants of the osteopontin gene and the metabolic environment in mediating vascular hypertrophy and atherosclerosis
Recent Peer Reviewed Publications
Dávila-Román VG, Vedala G, Herrero P, de las Fuentes L, Rogers JG, Kelly DP, Gropler RJ. Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2002;40: 271-277.
de las Fuentes L, Herrero P, Peterson LR, Kelly DP, Gropler RJ, Dávila-Román VG. Myocardial fatty acid metabolism is predictive of left ventricular hypertrophy in hypertensive heart disease. Hypertension 2003;41: 83-87.
Peterson LR, Schechtman KB, Ewald GA, Geltman EM, de las Fuentes L, Meyer T, Krekeler P, Moore ML, Rogers JG. Timing of Cardiac Transplantation in Patients With Heart Failure Receiving b-adrenergic Blockers. J Heart Lung Transplant 2003;22: 1141–1148.
Waggoner AD, Faddis MN, Gleva MJ, de las Fuentes L, Osborn J, Heuerman SL, Dávila-Román VG. Cardiac Resynchronization Therapy Acutely Improves Diastolic Function. J Am Soc Echocardiogr 2005;18: 216-20.
Waggoner AD, Faddis MN, Gleva MJ, de las Fuentes L, Davila-Roman VG. Improvements in left ventricular systolic dysfunction after cardiac resynchronization therapy are coupled to response in systolic performance. J Am Coll Cardiol 2005;46: 2244-2249.
de las Fuentes L, Brown AL, Waggoner AD, Dávila-Román VG. Plasma Triglyceride Level is an Independent Predictor of Left Ventricular Diastolic Function. J Am Soc Echocardiog 2005;18: 1285-1291.
Waggoner AD, Rovner, A, de las Fuentes L, Faddis MN, Gleva MJ, Sawhney N, Davila-Roman VG. Clinical Outcomes after Cardiac Resynchronization Therapy: Importance of Left Ventricular Diastolic Function and Etiology of Heart Failure. J Am Soc Echocardiog 2006;19:307-313.
Peterson LR, Waggoner AD, de las Fuentes L, Schechtman KB, McGill JB, Gropler RJ, Davila-Roman VG. Alterations in Left Ventricular and Left Atrial Structure and Diastolic Function in Type-1 Diabetics. J Am Soc Echocardiog 2006 (in press).
Rovner A, de las Fuentes L, Waggoner AD, Nemon N, Chohan R, Dávila-Román VG. Characterization of Left Ventricular Diastolic Function in Hypertension by Use of Tissue Doppler Imaging and Color M-Mode Techniques. J Am Soc Echocardiog 2006 (in press).
de las Fuentes L, Soto PF, Cupps BP, Pasque MK, Herrero P, Gropler RJ, Waggoner AD, Dávila-Román VG. Hypertensive left ventricular hypertrophy is associated with abnormal myocardial fatty acid metabolism and myocardial efficiency. J Nucl Cardiol 2006 (in press).
Dong SJ, de las Fuentes L, Brown AL, Waggoner AD, Ewald GA, Dávila-Román VG. NT-proBNP Levels: Correlation with Echocardiographically-determined Left Ventricular Filling Pressures in An Ambulatory Cohort. J Am Soc Echocardiog 2006 (in press).
Link to Cardiovascular Imaging and Clinical Research Core Laboratory